A review on caspases: key regulators of biological activities and apoptosis

G Sahoo, D Samal, P Khandayataray… - Molecular neurobiology, 2023 - Springer
… elegans and CED-4 protein is the stimulator for CED-3 activation while the CED-9 protein is
… zymogens and contain long pro-domains which allow them to interact with specific signalling …

Role of granule proteases in the life and death of neutrophils

C Benarafa, HU Simon - Biochemical and biophysical research …, 2017 - Elsevier
… neutral serine proteases such as cathepsin G and proteinase… for the activation of all
neutrophil serine proteases by the … While CatG has been shown to process pro-caspase-7 into …

The intricate biophysical puzzle of caspase-1 activation

NJ Makoni, MR Nichols - Archives of biochemistry and biophysics, 2021 - Elsevier
… 11 are activated by the non-canonical inflammasome pathway … idea that a protease with a
particular substrate specificity was … IDL, while activation of other caspases involves removal of …

[PDF][PDF] Cathepsin G inhibition by Serpinb1 and Serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammation

SS Burgener, NGF Leborgne, SJ Snipas, GS Salvesen… - Cell reports, 2019 - cell.com
… Serpinb6a inhibit the granule serine protease cathepsin G to … PR3 can directly activate
apoptotic pro-caspase-7 and pro-… cells through blockade of cell-specific, CatG-dependent RCD. …

Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts

HK Jun, YJ Jung, S Ji, SJ An, BK Choi - Cell Death & Differentiation, 2018 - nature.com
… G, a serine protease, has been reported to cleave recombinant pro-caspase-7 into a maximally
activated … Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. …

Caspases—at the cutting edge of cell death

HR Stennicke - Programmed Cell Death in Animals and Plants, 2021 - taylorfrancis.com
… shows numerous features that bear more resemblance to the serine proteases than to other
… (1997) Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity. …

Characterization of Caspase 1 Substrate Specificity Utilizing Luminescent Reporter Constructs

N Rohlfes - 2020 - search.proquest.com
… biosensor measuring protease activation has been used … is also non-canonical inflammasomes
that can be activated … the cleavage of the pro-caspase 7 protein by active caspase 1…

Lactoferrin is an allosteric enhancer of the proteolytic activity of cathepsin G

S Eipper, R Steiner, A Lesner, M Sienczyk, D Palesch… - PloS one, 2016 - journals.plos.org
… Neutrophils secrete serine proteases including cathepsin G (… Taken together, CatG
loses its substrate specificity in the … CatG-induced activation of platelets in a proteolytic-dependent …

Lysosomes in programmed cell death pathways: from initiators to amplifiers

N Kavčič, K Pegan, B Turk - Biological chemistry, 2017 - degruyter.com
… All CMA substrates contain in the sequence a specific … for non-canonical inflammasome
signalling by Gramme-negative bacteria and subsequent pyroptosis, as well as for activation of IL…

Cathepsin L participates in the remodeling of the midgut through dissociation of midgut cells and activation of apoptosis via caspase-1

C Yang, XW Lin, WH Xu - Insect biochemistry and molecular biology, 2017 - Elsevier
… bovine serum (FBS) because no cell line has been established from H. armigera. Apoptosis
… to activate the cysteine protease. Then, 5 μl of 1 mM Z-Phe-Arg-MCA (a specific substrate for …